Pills with effects that can't necessarily 'double' are stronger, i.e. Smaller enemies spawn 2-3 tears, and bosses spawn a maximum of 16, Tears from this effect maintain tear modifiers and status effects that Isaac currently has, Isaac doesn't take damage from the tears created by this item, Every time you take damage, a tiny Isaac familiar will spawn, which follows you and shoots tears at nearby enemies that deal 1.3 Damage, The mini-Isaacs stay with you between floors, but can die if they take too much damage, Maximum number of mini-Isaacs is 16 at one time, Mini-Isaac's keep some of the abilities and appearance that Isaac has - e.g. Unlocked from the 'Sin Collector' achievement (collect every Bestiary entry), Gulp! 12 Revelation. grey, gray, lamp, UNLOCK: Unlock this item by making a Super Bandage Girl, * boss room pool, boss room item, pink, plaster, sticker, item room, treasure room, item room pool, the lost item pool, When used Isaac transforms into pacman, which makes him invincible for 6 seconds and does 40 contact damage to enemies per chomp, Everytime you 'eat' 2 enemies, you regain 1/2 heart of red health, You can't shoot tears while the effect is active, UNLOCK: Unlock this item by visiting 10 arcades, * item room, treasure room, item room pool, gameboy, grey, gray, white, A bag that floats around following Isaac and drops a random coin every 2 rooms, UNLOCK: Unlock this item by beating Isaac with Cain, * secret room pool, item room, treasure room, item room pool, bag, purple, pouch, A familiar which follows Isaac and shoots lasers, similar to the Technology item, Robo-Baby's laser is spectral and piercing (It will pass through rocks and objects in the environment), Robo-Baby's lasers deal 3.5 damage per hit, * item room, treasure room, item room pool, robo baby, robot baby, white, grey, gray, silver, red, A familiar which follows Isaac and drops half a red heart every 3 rooms, UNLOCK: Unlock this item by beating the Caves 30 times and defeating C.H.A.D, * lil chad, little chad, item room, treasure room, item room pool, the lost item pool, red, smile, face, bug, Any pickups are possible from this item, including Bombs, hearts, keys, coins, pills, batteries, tarot cards, runes etc, Doesn't produce microbatteries, only regular sized ones and rarely golden/mega batteries, UNLOCK: Unlock this item by beating each of the Seven Sins once, Item Pool: Item Room, Library, Devil Room, * library pool, library room, book room pool, devil pool, devil room pool, devil deal, item room, treasure room, item room pool, red 7 book, grey, gray, black, A blue cross that follows Isaac and drops a soul heart every 7-8 rooms, REPENTANCE - The Relic now generates soul hearts less frequently, UNLOCK: Unlock this item by beating the Isaac boss with Maggy, * angel room pool, god room pool, angel room item, item room, treasure room, item room pool, REPENTANCE - Dead Sea Scrolls now displays the name of the given effect, and can no longer give Kamikaze. Function: Adds a special Angel room shop at the start of a new floor, Unlock Condition: Defeat Isaac as Jacob and Esau. spray, brown, white, yellow, moms purfume, Tears can now be charged and released in a shotgun style effect, much like Monstro's main attack, Partial charging does nothing - must be fully charged to use, * item room, treasure room, item room pool, pink, body part, monstros lung, On pickup Abaddon converts all your heart containers to black hearts, then gives you +2 more black hearts, Tears now have a chance to induce the fear effect, causing enemies to run away from Isaac for a short period, REPENTANCE - No longer kills Keeper when picked up, just reduces coin health to 1, UNLOCK: Unlock this item by beating the Chest with Azazel, * devil pool, devil room pool, devil deal, red devil sign, abandon, abadon, pentagram, Isaac leaves a trail of tar behind him which will slow down enemies that walk over it, Tears have a chance to slow enemies and their projectiles for a short period of time, The chance to slow enemies can improve based on your luck stat and will always slow enemies at +18 Luck, * item room, treasure room, item room pool, black, grey, gray, The Stop Watch applies a permanent but slight slowing effect to all enemies and their projectiles, The slowing effect has a reduced effect against Brimstone lasers fired by enemies, REPENTANCE - Stop Watch now slows down all enemies in the game once again, but the slow effect is much less drastic. Guppy's Head. After taking two hits, the fire will be extinguished, The Book can be held at the same time as another active item. Basement 1, Cathedral, Sheol etc. in The Chest floor as The Forgotten, Item Pool: Item Room, Greed Mode item Room, When picked up, this item replaces all of your red heart containers with 6 Bone Hearts, Every time you lose a bone heart, lots of bones fire in all directions damaging any enemies hit and you gain a permanent +0.5 Tears Up, For the Lost and Keeper characters, this item simply gives a permanent Tears Up, UNLOCK: Unlock this item by defeating The Lamb in the Dark Room floor as The Forgotten, Obtained by beating the Basement 1 boss within 1 minute, then bombing the large shadow that appears in the middle of the starting room, While held, Mom's Foot will stomp on you from above twice every few seconds, and she will continue to stomp for as long as you hold this item, Using the Broken Shovel will stop Mom stomping you for the rest of the current room (or current wave if you're in the boss rush or challenge room), Beating the Boss Rush while holding this item will drop the second half of the Broken Shovel, which combine to create Mom's Shovel, which is used to unlock The Forgotten character, Dropping the Broken Shovel will cause it to disappear if you leave the room, NOTE: This item will not drop unless you have beaten The Lamb at least once, Added as part of the Afterbirth+ Booster Pack #5 and used in the quest to unlock The Forgotten character, Drops after beating the Boss Rush while holding the other half of the Broken Shovel (see previous item for more details), Combines with the first Broken Shovel piece to create Mom's Shovel (see next item for more details), When used, spawns a trapdoor that leads to the next floor, Unlocks The Forgotten character when used on a mound of dirt that appears in a room in The Dark Room floor, Obtained by combining the two Broken Shovel pieces. Glitched Crown is in this list as the strongest among them once you learn how to pick out the item you want consistently. Takes more shots before breaking, Bomb poop - Throws a butt bomb that explodes after 2 seconds, UNLOCK: Unlock this item by defeating Delirium as Tainted Blue Baby, Allows you to quickly double tap a shoot button to sneeze on nearby enemies, dealing x1.5 your tear damage and pushing them back slightly, If an enemy is pushed into a wall or object it takes 10 damage, UNLOCK: Unlock this item by defeating Delirium as Tainted Azazel, Bombs become spectral and can now pass through objects, Bombs spawn a friendly white soul, which will hunt down other enemies, dealing contact damage which scales with your tear damage, After 10 seconds the white soul explodes dealing 7 damage to nearby enemies. * arcade, skull game, black, heart, pink, love, Gives Isaac 2 orbital flies which block enemy shots, Picking up this item as well as 2 other fly-type items will allow you to transform into Lord of the Flies, * item room, treasure room, item room pool, key master pool, key beggar pool, key judgement pool, two, flies, black, When revived, the green mushroom that follows Isaac will disappear and he will respawn with the same amount of red heart containers at full health, Resurrection takes place before all other items which give you an extra life, * secret room pool, mario, green mushroom, extra life, spots, spotted, x1.5 times Damage Multiplier (Does not stack with the multipliers from Cricket's Head / Blood of The Martyr + Book of Belial), Increases the size of your player sprite, but doesn't increase the hitbox, Counts as 1 of 3 mushroom items needed towards the Fun Guy transformation, Counts as 1 of 3 size-increasing items needed towards the Stompy transformation, * boss room pool, boss room item, item room, treasure room, item room pool, red, spots, spotted, amanita muscaria, Enemies touching you take 12 damage, then a poison effect is applied for 6-7 ticks, dealing damage equal to the amount of red hearts you have (up to 30.8 at 12 full red hearts), Has a chance to drop from the Lust miniboss fight, Counts as 1 of 3 syringe items needed towards the Spun transformation. Tech.5/Technology Zero/Jacobs Ladder: The extra damage is very helpful. Metronome: Isaac keeps any stat upgrades gained by a random temporary item as long as the item brings his stats over their highest value reached on that run. Nicalis, Inc. has announced that The Binding of Isaac: Repentance has been given a huge new update, bringing the DLC in line with the PC version of the game. the lost item pool, cat, bone, pink, grey, gray, guppys paw, guppy paw, Gives a 1/3 chance for room clear rewards to become a normal or locked chest, and a 1/3 chance to reward nothing at all, Doesn't affect coins dropped after waves in Greed Mode, * curse room pool, red chest pool, red chest item pool, devil pool, devil room pool, devil deal, item room pool, red, boom, tnt, * item room, treasure room, item room pool, wooden, cross, brown, Isaac can now hold two trinkets at the same time, Drops a random trinket on the floor when picked up, Allows you to pick up more trinkets while also holding The Tick, * shop room pool, shop item pool, purple, pink, bag, All of Isaac's bombs now leave a poison effect on any enemies within the blast radius, As well as dealing the standard 60 damage for a bomb, it will apply a Damage over Time effect that does 4 or 6 damage per tick, Has a chance to drop from the Super Sloth miniboss fight. When used, fills the entire room with poop! After killing a 25 more enemies, it transforms again dealing 15 damage and destroying obstacles it charges into. Battery - 6.6% chance, Also adds a 20% chance to spawn a fly if the original drop was a coin, UNLOCK: Unlock this trinket by defeating Isaac, ?? Find it . the lost item pool, white, A familiar that follows Isaac and can fire up and charge brimstone shots, exactly how the normal Brimstone item works but with less damage, Each laser deals 3 damage per tick, up to 8 times for a total of 31.5 damage, * devil pool, devil room pool, devil deal, item room, treasure room, item room pool, horns, baby, satanic, star, red, black, Instead of tears, Isaac now shoots bombs from his eyes, which explode dealing damage to anything nearby, Bombs will also synergize with other bomb items and tear modifiers, including Sad Bombs, Mr. Mega and many more, REPENTANCE - Dr. Fetus bombs now scale with the player's tear size and are now immune to knockback from their own explosions. shop room pool, shop item pool, cross, brown, Upon use, gives +2 damage up which lasts for the current room, x1.5 times Damage Multiplier if you also have Blood of the Martyr (Does not stack with Magic Mushroom or Cricket's Head multipliers), Increases your chances of getting a devil/angel room by +12.5%, REPENTANCE - The effect stacks if used multiple times, * library pool, library room, book room pool, devil pool, devil room pool, devil deal, starting the lost item pool, white, yellow, blue, When activated, Isaac takes out the axe and gives you the ability to break rocks and damage enemies with it, It has a limited amount of uses per floor, decreasing with every hit that connects with a rock/enemy, Cannot break the stone blocks which appear in the environment, Creates bridges when breaking rocks next to pits, Recharge Time: At the start of each new floor, * item room, treasure room, item room pool, minecraft, brown, grey, gray, silver, When Isaac gets hit, 2-6 blue flies will randomly spawn, REPENTANCE - Buffed, it used to spawn 1-3 flies each time, * item room, treasure room, item room pool, the lost item pool, bug, yellow, face, Isaac's tears are replaced with explosive poison bombs, which will arc upwards and explode on contact with the floor, dealing huge damage and leaving a poison effect on enemies in range, Ipecac shots are given a flat +40 Damage on top of the normal 3.5 base damage, Shots will damage Isaac if he is in the blast radius when they explode, REPENTANCE - Ipecac explosion size now scales with tear size, UNLOCK: Unlock this item by beating Mom's Heart 6 times, * item room, treasure room, item room pool, jar, bottle, purple, label, Isaac has a random chance to fire a tooth shot instead of a tear sometimes, Teeth shots deal damage equal to your tear damage * 3.2, The chance to fire a tooth is affected by your luck stat and at +9 Luck it will activate every time, Synergizes well with some tear modifiers such as Ipecac, which causes it to do massive damage, * item room, treasure room, item room pool, knuckle, dusters, four, silver, grey, gray, brass knuckles, Isaac has a 1/6 chance to spawn a blue fly when one of his tears hits an enemy, The chance to activate this effect is not changed with your Luck stat, * item room, treasure room, item room pool, heart, Isaac now also has a laser with unlimited range which fires continuously. If you have 1 or less heart containers, this pill becomes Health Up, Hematemesis - Empties all but one red heart container and spawns 1-4 red hearts on the floor. UNLOCK: Unlock this item by getting all hard mode completion marks for the 17 non-tainted characters, Combine with Knife Piece 2 to create a Knife which can be fired across the room, dealing 25 damage to any enemies it comes into contact with, In the Downpour/Dross II, you will find a white flame somewhere, and a room with a mirror in it. Counts as 1 of 3 book items needed towards the Bookworm transformation. 14 Psy Fly. To unlock this room easier, any breaking run or Greed Mode run is more likely to get the necessary Zodiac items. While at full red health you also shoot a projectile across the room with each swing, dealing your current Damage + 2 (similar to the Master Sword in Zelda), UNLOCK: Unlock this item by defeating challenge #39 (Isaac's Awakening), While held, a red outline of a door will appear on certain walls. All this stuff makes runs more versatile and fun, There is a lot more, just google mega satan unlocks and aim what you want. I was trying to remember what unlocked crane game. Beat the boss and move on to Corpse II to finally take on Mother. The effect triggers again 30 seconds after use and again 60 seconds after use, Something's wrong - Spawns a pool of black creep beneath Isaac, Vurp! binding of isaac: repentance unlock guide. UNLOCK: Unlock this item by beating Delirium on The Void floor with ??? The floor generation can fail and cause the guaranteed Planetarium to not spawn sometimes. Half hearts heal a whole heart and full hearts heal 2 red hearts, UNLOCK: Unlock this item by beating Boss Rush with Maggy, * item room, treasure room, item room pool, the lost item pool, pink, purple, candy, Each time you enter a new room, damage is negated for the first time you get hit, Can be used to go in and out of a Curse Room without taking damage. Based on the Steam Workshop mod created by Niro, A familiar with a charged attack, that spawns a line of creep on the floor which damages enemies that walk over it, The familiar and its creep will change randomly when Isaac uses a pill, Possible creep types include green (deals damage), black (slows enemies), red (deals damage, forms a line with a larger puddle), yellow (deals damage, forms a short-range cone) and white (slows enemies, forms a ring), Added as part of the Afterbirth+ Booster Pack #5. UNLOCK: Unlock this item by defeating Isaac as Jacob & Esau. They do not block enemy shots, UNLOCK: Unlock this item by defeating The Beast as Tainted Lilith, Isaac builds rage each time you clear a new room. This deals 1 damage per tick, High tear damage will cause this item to become very powerful for rooms with a lot of enemies, since they can die instantly and render the room harmless, Enemies which spawn after the first few seconds of each room are not affected by this item, e.g. Both the box and trinket are consumed when this happens, UNLOCK: Unlock this trinket by defeating Isaac, ?? (6 full hearts to fully charge), Unless fully charged, hearts picked up are consumed by the Alabaster Box, instead of being added to your life total. This is to prevent a syngery like Dr. Fetus or a Golden Bomb giving you infinite resources, Isaac's shadow will follow closely behind him and when it comes into contact with enemies, will spawn friendly dark charger mobs, The chargers deal contact damage to enemies, and will be killed if it is hurt too much, Chargers disappear upon entering a new room, UNLOCK: Unlock this item by beating Greed Mode with Judas, Every time you kill an enemy a fly will be added to the Jar, allowing you to stack up to 20, Using the Jar of Flies will release all the flies that are currently in the jar as friendly flies that will damage enemies, A Loki familiar that follows Isaac and shoots tears 4 tears in a cross pattern, dealing a flat 3.5 damage each, Gives Isaac a familiar glass of milk that follows him and spills on the floor upon taking damage, After being spilt, the milk gives you a -2 Tear Delay (Tears up) for the rest of the room, When used, the D7 will restart the current room and bring back all enemies once again, enabling you to farm rewards that spawn at the end after beating the room, Can be used to generate infinite consumable combinations, gaining as many coins/keys/bombs as you need, This item has no effect in Greed Mode, Challenge Rooms and rooms that had no enemies in originally, If used in a Boss Room or Angel/Devil Room, you get teleported to another random room, which is reset instead of the boss/angel/devil room you were in, Enemies respawned by the D7 don't drop loot if they were champions and also don't grant score in daily runs, * dice, pip, die, turban, white, grey, gray, Makes Isaac very small like a baby, reducing his hitbox size, When used, Mom's Box will drop a random trinket on the ground, While held, doubles the effect of trinkets which make sense to be doubled (e.g. The size resets when leaving the floor, UNLOCK: Unlock this item by defeating The Beast as Tainted Lazarus, A fetus familiar follows Isaac, and upon entering the Boss room on each floor, it will transform into a copy of the boss, This makes bosses a lot harder, however you now get 2 boss item drops, UNLOCK: Unlock this item by defeating Hush as Jacob & Esau, You gain two familiar demons, that stay by Isaac's side and fire shots in the same direction as you, The familiars deal roughly 40% of Isaac's damage, scaling with damage upgrades you get, They sit near and rotate around Isaac depending on which way you're firing tears. See the dedicated Devil room page for more details, First half of the key required to enter the door to the Mega Satan boss, Drops from one of the angels which appear by bombing the statue in an angel room, * angel room, angels, broken, yellow, gold, circle, Second half of the key required to enter the door to the Mega Satan boss, Randomly increases 4 of your stats, and decreases 2 of them, Possible stat changes are fixed values: 1 health, 1 damage, 0.2 speed, 0.5 range, 0.5 tears, 0.2 shot speed, 1 luck, UNLOCK: Unlock this item by beating Mom's Heart 7 times, * demon beggar pool, demon judgement pool, devil beggar pool, boss room pool, boss room item, item room, treasure room, item room pool, yellow syringe, needle, injection, Doubles pickups and chests from clearing a room, Also gives a 30% chance for room clear rewards to not spawn, Doesn't affect coins spawned in Greed Mode, * curse room pool, demon beggar pool, demon judgement pool, devil beggar pool, devil pool, ?s only friend, blue bozzy, An iron ball and chain attached to Isaac, similar to Guppy's Hairball that you can fling around to deal 5 damage per tick, The ball will block enemy shots and can also destroy environmental objects such as rocks, mushrooms and skulls, Does not decrease your movement speed stat at all however the ball has to be dragged around causing Isaac to slow down slightly when the chain is fully extended, UNLOCK: Unlock this item by beating Boss Rush with Samson, * secret room pool, item room, treasure room, item room pool, grey, gray, shackle, A familiar that will follow Isaac and copy the effect of one of your other familiars, If you don't have any other familiars, he will just shoot normal tears, REPENTANCE - Removed the double damage multiplier on Mongo Baby's attacks, * item room, treasure room, item room pool, pink, blue, grey, gray, An active item that fires 8 of Isaac's tears in a circle around him, Tears spawned from this item keep most effect that Isaac currently has applied to his tears, and deal an additional +5 flat damage, UNLOCK: Unlock this item by beating the Isaac boss with Isaac, * item room, treasure room, item room pool, glass, blue, water, isaacs tears, Upon use, teleports you to one of the following rooms at random: Item room, Secret room, Super secret room, the I AM ERROR room or the Black Market (very low chance), There are no I AM ERROR rooms on the final floors, preventing looping with this item, UNLOCK: Unlock this item by beating Boss Rush with Eden, * item room, treasure room, item room pool, pink, purple, red, broken, When used will cut your head from your body. Using the Satanic Bible or Book of Revelations has some side effects you might not want. as Bethany, Gives you a random syringe effect every room, The effect can be The Virus, Roid Rage, Speed Ball, Experimental Treatment, Synthoil, Euthanasia or Growth Hormones, Placed bombs explode after 0.66 seconds instead of the usual 1.5 seconds, This was called Exploded Firecracker in Antibirth, Farts produced by Isaac or familiars will be twice as large, Chance for enemies to burn when entering a room, The chance for this effect to activate is effected by your Luck stat, This includes key blocks and golden chests, Pickups left on current floor will appear in the starting room of the next floor, up to a maximum of 4 pickups, Active items will be rerolled upon using them, Using with Book of Virtues will only reroll the item the book is holding, Has no effect with Notched Axe due to how its durability works, UNLOCK: Unlock this trinket by defeating Mother as Eden, Random luck-based tear effects have an extra chance of occurring, The additional chance is effectively +3 Luck Up, Picking up red hearts now has a high chance to spawn 1-4 blue attack spiders, instead of giving you health back, This effect also works while fully healed, giving a guaranteed chance of getting spiders, While missing any red health the chance for spiders is less, Works for characters that don't use red health, which always gives you spiders, Hearts in Shops can be converted into spiders for free, Gives your familiars improved rate of fire while held, In Antibirth this trinket was called Song of the Siren, UNLOCK: Unlock this trinket by bombing the skull left by The Siren boss after her death, While held at the start of each floor, this trinket spawns four wisp familiar orbitals around Isaac, These wisps are the same as the ones created by the Book of Virtues item, UNLOCK: Unlock this trinket by beating the Boss Rush as Bethany, Your active item no longer gains charges, but battery drops become much more common, UNLOCK: Unlock this trinket by blowing up 10 Battery Beggars, Tears that miss enemies will redirect themselves and travel 90 degrees towards enemies, Tears must be roughly 2 tiles or closer to activate this effect, +10 Luck while held, but the trinket is destroyed when damage is taken, Blood donation machines, Curse Rooms and Sacrifice Rooms wont destroy it, Taking a hit and activating Holy Mantle won't destroy it, Can be dropped in order to avoid breaking it, This trinket is automatically given to you after clearing 3 bosses without taking damage, Treasure Rooms are replaced with Red Treasure Rooms, which contain a deal with the devil in place of a regular item pedestal, If an item room has not yet been entered, it can be transformed to either a regular or Red Treasure Room by picking up or dropping this trinket before entering, Does not affect the mirrored treasure room in Downpour II, UNLOCK: Unlock this trinket by defeating Mother as Azazel, Every time you pick up a coin, you have a small chance to gain 1 bar of charge on your active item, The chance for this effect to happen is 1/6th of the value of the coin picked up, Can only activate once per coin collected, In Antibirth this trinket was called Electric Penny, UNLOCK: Unlock this trinket by donating to a battery beggar until he pays out with an item 5 times, While held, your familiars will now orbit around Isaac instead of following behind him, Activates your active item just before damage would be taken, It doesn't activate for free - the charges are used up as normal if this effect activates. 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