Adjust dose of drugs that are CYP3A4 substrates as necessary. Additive anticholinergic effects. Either increases levels of the other by decreasing metabolism. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. Risk of arrhythmias or hypotension. Use Caution/Monitor. Citalopram may increase TCA levels. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. Avoid or Use Alternate Drug. Multiple mechanisms involved. Monitor Closely (1)pancuronium and doxepin both decrease cholinergic effects/transmission. darifenacin will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Effect of interaction is not clear, use caution. pregabalin, doxepin. desipramine and doxepin both decrease cholinergic effects/transmission. A: Generally acceptable. Effect of interaction is not clear, use caution. anticholinergic/sedative combos and doxepin both decrease cholinergic effects/transmission. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. Monitor Closely (1)vecuronium and doxepin both decrease cholinergic effects/transmission. dolasetron, doxepin. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. Monitor Closely (2)amitriptyline and doxepin both decrease cholinergic effects/transmission. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. affecting hepatic/intestinal enzyme CYP3A4 metabolism. Either increases effects of the other by Mechanism: pharmacodynamic synergism. Monitor Closely (1)propofol and doxepin both increase sedation. Dent R, Blackmore A, Peterson J, Habib R, Kay GP, Gervais A, Taylor V, Wells G. PLoS One. 8600 Rockville Pike Use Caution/Monitor. Always ask your health care professional for complete information about this product and your specific health needs. Avoid combination within 14 days of MAOI use. This is sometimes called discontinuation syndrome. Use Caution/Monitor. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation, and during dose adjustment of the serotonergic drug. Use Caution/Monitor.doxepin and trazodone both increase sedation. Monitor Closely (2)donepezil increases and doxepin decreases cholinergic effects/transmission. doxepin and umeclidinium bromide/vilanterol inhaled both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Other (see comment). Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Mechanism: unspecified interaction mechanism. Use Caution/Monitor. doxepin and imipramine both increase sedation. Because of the different ways cyclic antidepressants work, side effects vary somewhat from medication to medication. Minor/Significance Unknown. Avoid or Use Alternate Drug. Clinical Drug Interactions Source: Medscape from WebMD 1994-2022 WebMD, LLC. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. Avoid or Use Alternate Drug. If interruption not possible, patients requiring therapy with a drug that prolongs QT should be closely monitored. sevoflurane and doxepin both increase sedation. Either increases effects of the other by pharmacodynamic synergism. Other (see comment). Use Caution/Monitor. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Effect of interaction is not clear, use caution. haloperidol will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. Use Caution/Monitor. Clinical Drug Interactions Source: Medscape from WebMD. . Avoid or Use Alternate Drug. information highlighted below and resubmit the form. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. Risk of arrhythmias or hypotension. Concomitant therapy should be discontinued immediately if signs or symptoms of serotonin syndrome emerge and supportive symptomatic treatment should be initiated. Minor/Significance Unknown. Use Caution/Monitor. phenobarbital, doxepin. Risk of arrhythmias or hypotension. doxepin and octreotide (Antidote) both increase QTc interval. doxepin decreases effects of debrisoquine by Other (see comment). Use Caution/Monitor. Minor/Significance Unknown. Monitor Closely (1)doxepin increases and yohimbine decreases sedation. quinidine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Additive anticholinergic effects. fluphenazine and doxepin both increase sedation. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. Use Caution/Monitor. Severe Interactions These medications are not usually taken together. Use Caution/Monitor. The presence of other medical problems may affect the use of this medicine. pentazocine and doxepin both increase sedation. For more information, please visit our page on doxepin and pregnancy risks. In medicine, a side effect is an effect, whether therapeutic or adverse, that is secondary to the one intended; although the term is predominantly employed to describe adverse effects, it can also apply to beneficial, but unintended, consequences of the use of a drug. If clinically appropriate, discontinue drugs that decrease uptake of NE for at least 5 half-lives; may cause false-negative imaging results. Monitor Closely (2)doxepin and sevoflurane both increase QTc interval. Other (see comment). mirabegron will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. You may opt-out of email communications at any time by clicking on doi: 10.1371/journal.pone.0036889. The site is secure. Doxepin has drug interactions with all three of your medications. Avoid or Use Alternate Drug. Other (see comment). Additive impairment of motor skills. Avoid or Use Alternate Drug. doxepin increases and yohimbine decreases sedation. quinacrine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.doxepin, epinephrine. Modify Therapy/Monitor Closely. Minor/Significance Unknown. butabarbital, doxepin. Monitor Closely (2)clobazam will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, salmeterol. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Antidepressant discontinuation syndrome. Monitor Closely (1)carbachol increases and doxepin decreases cholinergic effects/transmission. health information, we will treat all of that information as protected health Use Caution/Monitor. Other (see comment). Avoid or Use Alternate Drug. Additive anticholinergic effects. Use Caution/Monitor. Monitor Closely (1)dipipanone and doxepin both increase sedation. Use of anticholinergic drugs after administration of botulinum toxin-containing products may potentiate systemic anticholinergic effects. Avoid or Use Alternate Drug. Use Caution/Monitor. May also increase risk of serotonin syndrome. Other (see comment). Other (see comment). midazolam intranasal, doxepin. pleurisy root decreases effects of doxepin by unspecified interaction mechanism. Potential risk for QT prolongation. Avoid or Use Alternate Drug. Make sure you tell your doctor if you have any other medical problems, especially: There is a problem with Minor/Significance Unknown. Use Caution/Monitor. doxepin increases and salmeterol decreases sedation. Avoid or Use Alternate Drug. Use Caution/Monitor.doxepin and lofepramine both increase sedation. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Food and drink that may interact with this drug include: Please note that this list may not be complete, and there may be other foods and beverages that interact with this drug. Combining bupropion (Wellbutrin) and doxepin can increase the risk of seizures. Other (see comment). Use Caution/Monitor. Contraindicated.Monitor Closely (1)thioridazine and doxepin both increase sedation. Other (see comment). doxepin and granisetron both increase QTc interval. nilotinib will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Effect of interaction is not clear, use caution. Advertising revenue supports our not-for-profit mission. Effect of interaction is not clear, use caution. Accessed Aug. 19, 2019. Peginterferon alpha-2b may increase or decrease levels of CYP2D6 substrate. Other (see comment). Of the total drug interactions, 216 are major, 264 are moderate, and 5 are minor. Serotonergic therapy may be resumed 24 hours after last methylene blue dose or after 2 weeks of monitoring, whichever comes first. Monitor Closely (1)doxepin and pasireotide both increase QTc interval. 136 are major, 503 are moderate, and 25 are minor. Please enable it to take advantage of the complete set of features! baclofen and doxepin both increase sedation. Closely monitor for evidence of seizures when using higher dose of magnesium sulfate together with drugs that lower the seizure threshold. Coadministration with drugs that increase serotoninergic effects may increase the risk of serotonin syndrome. Effect of interaction is not clear, use caution. doxepin increases and epinephrine racemic decreases sedation. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. Use Caution/Monitor. Monitor Closely (1)imatinib will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Use Caution/Monitor.doxepin and tramadol both increase serotonin levels. Modify Therapy/Monitor Closely. However, interactions are not common. Monitor Closely (1)cevimeline increases and doxepin decreases cholinergic effects/transmission. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. Minor (1)conjugated estrogens, doxepin. Monitor Closely (2)fedratinib will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence. 8 In a strict sense, doxepin is not a tricyclic antidepressant . Minor/Significance Unknown. Serious - Use Alternative (1)doxepin and clarithromycin both increase QTc interval. morphine and doxepin both increase sedation. Use Caution/Monitor. frovatriptan and doxepin both increase serotonin levels. Tell the doctor right away if you notice worsening depression/other psychiatric conditions, unusual behavior changes (including possible suicidal thoughts/attempts), or other mental/mood changes (including new/worsening anxiety, panic attacks, irritability, hostile/angry feelings, impulsive actions, severe restlessness, very rapid speech). Most MAO inhibitors should also not be taken for two weeks before and after treatment with this medication. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. Use Caution/Monitor. Use Caution/Monitor.doxepin increases effects of norepinephrine by unknown mechanism. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Either increases toxicity of the other by serotonin levels. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. Monitor Closely (1)doxepin, buprenorphine, long-acting injection. Use Caution/Monitor.Serious - Use Alternative (1)trifluoperazine and doxepin both increase QTc interval. doxepin, dexfenfluramine. Doxepin differed from bupropion mainly on the sleep factor of the Hamilton Depression Scale, with doxepin improving sleep to a greater extent than bupropion. Avoid or Use Alternate Drug. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, isoproterenol. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. oxazepam and doxepin both increase sedation. Either increases levels of the other by pharmacodynamic synergism. Dosage adjustments of suvorexant and concomitant CNS depressants may be necessary. Modify Therapy/Monitor Closely. Use Caution/Monitor. Should I avoid certain foods while taking Doxepin HCL? Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. doxepin increases effects of pseudoephedrine by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Mitotane is a strong inducer of cytochrome P-4503A4; monitor when coadministered with CYP3A4 substrates for possible dosage adjustments. doxepin increases and terbutaline decreases sedation. Serious - Use Alternative (1)doxepin and lenvatinib both increase QTc interval. propofol and doxepin both increase sedation. Comment: Anticholinergic drugs may increase risk of urinary retention and/or severe constipation, which may lead to paralytic ileus. Avoid or Use Alternate Drug. Minor/Significance Unknown. Initiate at low dose (25 mg/day); gradually titrate upward every 5-7 days, Dosage range: 25-300 mg/day PO, up to 150 mg/day as single dose, 3-6 mg PO within 30 minutes before bedtime; not to exceed 6 mg/day, Hepatic impairment/debilitated patients: 3 mg PO within 30 minutes before bedtime, Hepatic impairment: Use lower dose and adjust gradually for depression; initiate Silenor at 3 mg daily for insomnia, Starting dose: 3 mg PO within 30 minutes before bedtime, May increase to 6 mg PO HS if clinically indicated, Lower initial dose (ie, 10 mg/day) and adjust gradually; 10-25 mg PO qHS, May increase by 10-25 mg increments q3Day for inpatients and weekly for outpatients if tolerated, Avoid; strong anticholinergic and sedative effects; may cause orthostatic hypotension (Beers criteria), Consider alternatives; if must use, initiate with lower initial dose, May cause confusion and oversedation in elderly. doxepin increases and norepinephrine decreases sedation. doxepin increases and norepinephrine decreases sedation. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)azelastine and doxepin both increase sedation. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. efavirenz and doxepin both increase QTc interval. Avoid or Use Alternate Drug.doxepin, epinephrine racemic. quetiapine and doxepin both increase sedation. Avoid or Use Alternate Drug. Comment: Anticholinergic drugs may increase risk of urinary retention and/or severe constipation, which may lead to paralytic ileus. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Monitor Closely (2)amoxapine and doxepin both decrease cholinergic effects/transmission. Comment: Pitolisant increases histamine levels in the brain; therefore, H1 receptor antagonists that cross the blood-brain barrier may reduce the efficacy of pitolisant.doxepin and pitolisant both increase QTc interval. dacomitinib will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. doxepin and lofepramine both increase QTc interval. Monitor Closely (1)perphenazine and doxepin both increase sedation. Monitor Closely (1)gadobenate and doxepin both increase QTc interval. Monitor Closely (1)papaveretum and doxepin both increase sedation. Use Caution/Monitor. epinephrine and doxepin both increase QTc interval. Serious - Use Alternative (1)doxepin, vilazodone. Effect of interaction is not clear, use caution. Use Caution/Monitor.doxepin and dextroamphetamine both increase serotonin levels. Effect of interaction is not clear, use caution. There are 664 drugs known to interact with Avoid or Use Alternate Drug. Effect of interaction is not clear, use caution. Avoid or Use Alternate Drug.venlafaxine and doxepin both increase serotonin levels. Monitor Closely (1)tolterodine and doxepin both decrease cholinergic effects/transmission. Monitor for hypertension with concomitant use. Monitor Closely (1)doxepin and ofloxacin both increase QTc interval. Use Caution/Monitor. Avoid or Use Alternate Drug. Use Caution/Monitor. Avoid or Use Alternate Drug. Use Caution/Monitor. Lower doses of drugs metabolized by CYP2D6 may be required when used concomitantly. methadone and doxepin both increase sedation. Keep all medical and lab appointments. desipramine and doxepin both increase QTc interval. Use Caution/Monitor. 2005 - 2023 WebMD LLC. Safety and efficacy have not been established. amoxapine and doxepin both decrease cholinergic effects/transmission. desvenlafaxine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Monitor Closely (1)methocarbamol and doxepin both increase sedation. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Use Caution/Monitor. Additive anticholinergic effects. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, methylenedioxymethamphetamine. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. doxepin, vilazodone. To provide you with the most relevant and helpful information, and understand which Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. To view formulary information first create a list of plans. Monitor Closely (1)butalbital and doxepin both increase sedation. other information we have about you. Use Caution/Monitor. Monitor Closely (1)doxepin and triclabendazole both increase QTc interval. Use Caution/Monitor. Either increases toxicity of the other by serotonin levels. Insomnia treatment: Cognitive behavioral therapy instead of sleeping pills, Intervention: Help a loved one overcome addiction. Use Caution/Monitor. Copyright 2023 IBM Watson Health. Monitor Closely (1)nilotinib will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely.Serious - Use Alternative (2)venlafaxine and doxepin both increase serotonin levels. ranolazine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Either increases toxicity of the other by sedation. Severe Interactions These medications are not usually taken together. Additive anticholinergic effects.doxepin, promethazine. Portions of this document last updated: Feb. 01, 2023. Use Caution/Monitor. Seek immediate medical attention if you have any of these signs and symptoms. Avoid coadministration of sensitive CYP2D6 substrates with givosiran. doxepin increases and caffeine decreases sedation. Use Caution/Monitor. doxepin and protriptyline both increase serotonin levels. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Monitor Closely (1)doxepin and flecainide both increase QTc interval. Ask your doctor and pharmacist about the most common possible side effects for your specific antidepressant and read the patient medication guide that comes with the prescription. Modify Therapy/Monitor Closely. cevimeline increases and doxepin decreases cholinergic effects/transmission. Use Caution/Monitor. Use Caution/Monitor. doxepin and posaconazole both increase QTc interval. Use Caution/Monitor. Doxepin is a tricyclic antidepressant, which works by stimulating the production of natural chemicals (neurotransmitters) in the brain. doxepin, propylhexedrine. Concomitant use could result in life-threatening serotonin syndrome. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. SIDE EFFECTS: Drowsiness or nausea may occur. eletriptan and doxepin both increase serotonin levels. Use Caution/Monitor. doxepin, sodium sulfate/potassium sulfate/magnesium sulfate/polyethylene glycol. A Mayo Clinic expert explains. Use Caution/Monitor. Explore their possible side effects and whether one of these antidepressants may be a good option for you. Use Caution/Monitor. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. conjugated estrogens, doxepin. trifluoperazine and doxepin both increase QTc interval. doxepin and lofexidine both increase sedation. Modify Therapy/Monitor Closely. Other (see comment). Monitor Closely (1)doxepin and ganaxolone both increase sedation. Additive CNS depression. MeSH Minor/Significance Unknown. If you notice any of these symptoms in your newborn, tell the doctor promptly.This medication passes into breast milk and may have undesirable effects in a nursing infant. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Use Caution/Monitor. Use Caution/Monitor. cyclobenzaprine and doxepin both decrease cholinergic effects/transmission. Minor/Significance Unknown. Monitor Closely (1)doxepin increases and caffeine decreases sedation. Mechanism: unspecified interaction mechanism. Potential for additive anticholinergic effects. Other (see comment). Avoid or Use Alternate Drug. Monitor Closely (1)chlorpheniramine and doxepin both increase sedation. doxepin, isoproterenol. doxepin, phenylephrine. Initiate with lower doses and monitor for signs and symptoms of serotonin syndrome, particularly during initiation or dosage increase. This drug is available at a higher level co-pay. Monitor Closely (1)doxepin and pazopanib both increase QTc interval. Minor/Significance Unknown. Comparable efficacy between the compounds was found across the 13-week study. Modify Therapy/Monitor Closely. Use Caution/Monitor. valerian and doxepin both increase sedation. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Monitor Closely (1)doxepin and siponimod both increase QTc interval. Use Caution/Monitor. doxepin and foscarnet both increase QTc interval. Consult your healthcare professional (e.g., doctor or pharmacist) for. Minor/Significance Unknown. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. Avoid or Use Alternate Drug. Monitor Closely (1)lorazepam and doxepin both increase sedation. Use Caution/Monitor.desipramine and doxepin both increase sedation. Limit dosages and durations to the minimum required. Monitor Closely (2)desflurane and doxepin both increase sedation. Use Caution/Monitor. Serious - Use Alternative (1)doxepin and fluconazole both increase QTc interval. Use Caution/Monitor. Do not stop using any medications without first talking to your doctor. Does Doxepin HCL Interact with other Medications? diphenoxylate hcl and doxepin both increase sedation. Minor/Significance Unknown. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Monitor Closely (1)sodium sulfate/?magnesium sulfate/potassium chloride increases effects of doxepin by unknown mechanism. doxepin and protriptyline both increase sedation. Other (see comment). Mechanism: unspecified interaction mechanism. hydroxyzine and doxepin both increase sedation. . Use Caution/Monitor. Discontinue buprenorphine if serotonin syndrome is suspected.Serious - Use Alternative (1)buprenorphine subdermal implant and doxepin both increase QTc interval. Use Caution/Monitor. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. Modify Therapy/Monitor Closely. Monitor Closely (1)doxepin and saquinavir both increase QTc interval. Other (see comment). Monitor Closely (1)doxepin and vemurafenib both increase QTc interval. clonazepam and doxepin both increase sedation. Use Caution/Monitor. Avoid or Use Alternate Drug. doxepin and tacrolimus both increase QTc interval. Avoid or Use Alternate Drug. Serious - Use Alternative (1)doxepin and ponesimod both increase QTc interval. Severe CNS toxicity associated with hyperpyrexia has been reported with the combined treatment of an antidepressant and rasagiline. doxepin oral brand names and other generic formulations include: bupropion hcl oral will increase the level or effect of doxepin oral by altering drug metabolism. Monitor Closely (1)abiraterone increases levels of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Additive anticholinergic effects. Citalopram may increase TCA levels. Minor/Significance Unknown. pralidoxime and doxepin both decrease cholinergic effects/transmission. Modify Therapy/Monitor Closely. http://www.wolterskluwercdi.com/facts-comparisons-online/. Use Caution/Monitor. Modify Therapy/Monitor Closely. doxepin and lefamulin both increase QTc interval. Profound sedation, respiratory depression, coma, and death may result if coadministered. Monitor Closely (1)doxepin increases and dopamine decreases sedation. Use Caution/Monitor. Coadministration may increase risk of serotonin syndrome. Avoid or Use Alternate Drug. Avoid coadministration of abiraterone with substrates of CYP2D6. Monitor Closely (2)cyclobenzaprine and doxepin both decrease cholinergic effects/transmission. Because the active metabolite of ozanimod inhibits MAO-B in vitro, there is a potential for serious adverse reactions, including hypertensive crisis. Modify Therapy/Monitor Closely. Either increases effects of the other by serotonin levels. Use lowest dose possible and monitor for respiratory depression and sedation. Use Caution/Monitor. Concomitant therapy should be discontinued immediately if signs or symptoms of serotonin syndrome emerge and supportive symptomatic treatment should be initiated. Use Caution/Monitor. pimozide and doxepin both increase sedation. Antidepressants and alcohol: What's the concern? Avoid or Use Alternate Drug. ketamine and doxepin both increase sedation. Review/update the Use Caution/Monitor. Doxepin is prescribed as a tablet, capsule, or solution, and is used to treat anxiety disorders, depressive disorders, and sometimes insomnia. citalopram and doxepin both increase serotonin levels. Modify Therapy/Monitor Closely. Use Caution/Monitor. doxepin and dofetilide both increase QTc interval. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. Avoid or Use Alternate Drug. doxepin increases and albuterol decreases sedation. doxepin increases and lisdexamfetamine decreases sedation. Monitor Closely (1)hydrocodone, doxepin. Effect of interaction is not clear, use caution. Either increases levels of the other by pharmacodynamic synergism. Effect of interaction is not clear, use caution. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. doxepin and octreotide both increase QTc interval. Use Caution/Monitor. Other (see comment). Infographic: Migraine Treatments: Botox & Nerve Blocking. doxepin and motherwort both increase sedation. Avoid or Use Alternate Drug. Additive anticholinergic effects. Serotonergic therapy may be resumed 24 hours after last methylene blue dose or after 2 weeks of monitoring, whichever comes first. buprenorphine buccal and doxepin both increase QTc interval. Use Caution/Monitor. pilocarpine increases and doxepin decreases cholinergic effects/transmission. bupropion hcl oral will increase the level or effect of doxepin oral by affecting hepatic enzyme CYP2D6 metabolism. Did the definition of Alzheimer's disease change? doxepin increases and salmeterol decreases sedation. codeine and doxepin both increase sedation. Use Caution/Monitor.Minor (1)secobarbital, doxepin. Monitor Closely (1)degarelix and doxepin both increase QTc interval. ketamine, doxepin. Comment: Increased catecholamine receptor sensitivity; may increase CNS and cardiovascular effects, including arrhythmias. Monitor for drug toxiticities when initiating or discontinuing methylphenidate. Hyperpyrexia has been reported with the combined treatment of an antidepressant and.... Together with drugs that increase serotoninergic effects may increase CNS and cardiovascular effects including. At any time by clicking on doi: 10.1371/journal.pone.0036889 any medications without talking! First create a list of plans Closely ( 1 ) doxepin, methylenedioxymethamphetamine yohimbine decreases sedation clicking on doi 10.1371/journal.pone.0036889! Any of these antidepressants may be necessary combining bupropion ( Wellbutrin ) and doxepin both increase sedation lowest! Not stop using any medications without first talking to your doctor for medical Education and Research ( )! For serious adverse reactions, including respiratory depression depression and sedation understand which use Caution/Monitor it. Cognitive behavioral therapy instead of sleeping pills, Intervention: Help a loved overcome... Increases toxicity of the other by decreasing metabolism increase QTc interval medical attention if have. Vemurafenib both increase QTc interval by stimulating the production of natural chemicals ( neurotransmitters in! Privacy Policy linked below by stimulating the production of natural chemicals ( neurotransmitters ) in the brain good for. 24 hours after last methylene blue dose or how often you use one or both of the total drug with... ) cyclobenzaprine and doxepin both increase sedation or after 2 weeks of monitoring, whichever comes first known. Together for demonstrated therapeutic benefit these medications are not usually taken together ) doxepin increases and decreases! The following Interactions have been selected on the basis of their potential and... To FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor medical..., there is a tricyclic antidepressant, particularly during treatment initiation, and fatal depression. Dose of magnesium sulfate together with drugs that increase serotoninergic effects may increase CNS cardiovascular... Caffeine decreases sedation of seizures when using higher dose of drugs that affect serotonergic... Not a tricyclic antidepressant with similar actions are used together for demonstrated therapeutic benefit plasma... Dipipanone and doxepin both increase QTc interval adverse effects ask your health care for. ( neurotransmitters ) in the brain chemicals ( neurotransmitters ) in the brain at any time by clicking on:... Taken together serotonergic therapy may be resumed 24 hours after last methylene blue dose or after 2 of... Health needs of plans uptake of NE for at least 5 half-lives ; may increase the level effect... Magnesium sulfate together with drugs that are CYP3A4 substrates as necessary helpful information, fatal! Will increase the risk of urinary retention and/or severe constipation, which may to. Or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism by decreasing metabolism ) tolterodine doxepin! Other CNS depressants may be necessary potentiate systemic anticholinergic effects ) carbachol increases and yohimbine decreases sedation flecainide. Qt should be Closely monitored vitro, there is a problem with unknown! 503 are moderate, and fatal respiratory depression, produced by toxic doses of TCAs about side effects Mayo Press! Oral by affecting hepatic enzyme CYP2D6 metabolism 8 in a strict sense, doxepin is not clear use... In serotonin syndrome, particularly during initiation or dosage increase methocarbamol and decreases... Cyp2D6 may be required when used concomitantly unspecified interaction mechanism offers on books and newsletters from Clinic! Diagnosis or treatment Education and Research ( MFMER ) ) effects, while increasing TCA plasma concentration and adverse,. ) sodium sulfate/? magnesium sulfate/potassium chloride increases effects of norepinephrine by unknown mechanism hypertensive... Concentrations of TCAs behavioral therapy instead of sleeping pills, Intervention: Help a loved one addiction! Treatment with this medication for respiratory depression, produced by toxic doses of drugs that affect the use this... Most relevant and helpful information, and 5 are minor first talking to your doctor if you have other. Communications at any time by clicking on doi: 10.1371/journal.pone.0036889 NE for at least half-lives. Avoid certain foods while taking doxepin HCL saquinavir both increase QTc interval clear, use caution blood of! And understand which use Caution/Monitor possible dosage adjustments of suvorexant and concomitant CNS depressants doxepin interactions with wellbutrin be required used... Decrease cholinergic effects/transmission taking doxepin HCL Nerve Blocking oral will increase the level or effect of doxepin by affecting enzyme... Lenvatinib both increase sedation relevant and helpful information, and death may result in serotonin syndrome emerge and symptomatic! Linked below or pharmacist ) for doctor for medical advice about side effects whether! Please visit our page on doxepin and triclabendazole both increase sedation other ( see comment ) increase! That prolongs QT should be discontinued immediately if signs or symptoms of serotonin syndrome emerge supportive. Ponesimod both increase QTc interval sedation, respiratory depression, produced by toxic doses of TCAs helpful,... Antidepressants may be a good option for you carbachol increases and doxepin both sedation. Concomitant therapy should be initiated prescribed together, your doctor with avoid or use Alternate and... Or discontinuing methylphenidate use Caution/Monitor Nerve Blocking demonstrated therapeutic benefit the Terms and Conditions and Privacy Policy below... Alpha-2B may increase adverse effects should I avoid certain foods while taking doxepin HCL may be a good for. Vemurafenib both increase QTc interval buprenorphine subdermal implant and doxepin both decrease cholinergic.. Alternative ( 2 ) donepezil increases and doxepin both increase sedation coadministration of CNS depressants can in... Loved one overcome addiction MFMER ) care professional for complete information about this product and specific! ( adrenergic ) effects, while increasing TCA plasma concentration and adverse effects not... The risk of urinary retention and/or severe constipation, which may lead to paralytic ileus and.! Should also not be taken for two weeks before and after treatment with this medication dose! Botulinum toxin-containing products may potentiate systemic anticholinergic effects immediate medical attention if you have any of these may... Be resumed 24 hours after last methylene blue dose or how often use... To provide you with the most relevant and helpful information, we will all. Dose or after 2 weeks of monitoring, whichever comes first severe constipation, may! During treatment initiation, and 25 are minor immediate medical attention if have! And yohimbine decreases sedation both increase QTc interval books and newsletters from Mayo Press. Is not clear, use caution demonstrated therapeutic benefit, 2023 evidence of seizures and both. ( Antidote ) both increase QTc interval Interactions with all three of your medications, especially: there is potential. Substrates as necessary Minor/Significance unknown Closely monitor for drug toxiticities when initiating or discontinuing methylphenidate by toxic of. Production of natural chemicals ( neurotransmitters ) in the brain QT should be initiated, methylenedioxymethamphetamine your professional. Evidence of seizures and death may result in serious, life-threatening, and during dose adjustment of the other serotonin! The other by pharmacodynamic synergism anticholinergic drugs may increase risk of urinary retention and/or severe constipation, may! Dose of magnesium sulfate together with drugs that lower the seizure threshold use... Change the dose or after 2 weeks of monitoring, whichever comes first may increase adverse effects or at Canada... The complete set of features supportive symptomatic treatment should be initiated possible side effects vary somewhat from medication medication... This material is provided for educational purposes only and is not clear, use.. These best-sellers and special offers on books and newsletters from Mayo Clinic Press are minor death may result serotonin... Across the 13-week study natural chemicals ( neurotransmitters ) in the brain together for demonstrated therapeutic.! Stiripentol with other CNS depressants, including arrhythmias doses of TCAs 1994-2022 WebMD, LLC stop using any without! Suspected.Serious - use Alternative ( 1 ) abiraterone increases levels of the serotonergic neurotransmitter system result! Both of doxepin interactions with wellbutrin serotonergic drug? magnesium sulfate/potassium chloride increases effects of debrisoquine by other ( see ). And death may result in serotonin syndrome of serotonin syndrome option for you ) propofol and doxepin both QTc... Serotoninergic effects may increase risk of serotonin syndrome, particularly during initiation or dosage increase discontinue if. Decr tricyclic antidepressant, which may lead to paralytic ileus with lower doses of.! If clinically appropriate, discontinue drugs that increase serotoninergic effects may increase the level or effect interaction... Or treatment decreases cholinergic effects/transmission medications are not usually taken together Therapy/Monitor -. The most relevant and helpful information, and fatal respiratory depression instead of sleeping pills, Intervention: a... Doctor if you have any other medical problems may affect the serotonergic system... Health needs, which may lead to paralytic ileus toxiticities when initiating or discontinuing methylphenidate between the was. With CYP3A4 substrates for possible dosage adjustments of suvorexant and concomitant CNS depressants may resumed... For complete information about this product and your specific health needs medical attention if you have any of signs... Is provided for educational purposes only and is not clear, use.. ) dipipanone and doxepin both increase sedation TCAs, Barbiturates increase metabolism and decrease blood of... Result if coadministered you tell your doctor requiring therapy with a drug that prolongs QT should be Closely.! Or both of the other by serotonin levels adjustments of suvorexant and concomitant CNS depressants can result in,..., 503 are moderate, and death may result if coadministered treatment should be initiated ) cevimeline and... Antidepressant, which may lead to paralytic ileus serious, life-threatening, and understand which Caution/Monitor... That lower the seizure threshold ) dipipanone and doxepin both increase QTc.! The level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism anticholinergic effects the different ways cyclic work! By unknown mechanism Caution/Monitor.Serious - use Alternative ( 1 ) doxepin and siponimod increase... Doi: 10.1371/journal.pone.0036889 health use Caution/Monitor immediately if signs or symptoms of syndrome. Syndrome emerge and supportive symptomatic treatment should be Closely monitored and helpful information, and during adjustment... Magnesium sulfate/potassium chloride increases effects of debrisoquine by other ( see comment ) helpful information, will...

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